Munschauer Lab

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TABLE Game 1 Game 2 Game 3 Total
Anna 144 123 218 485
Bill 90 175 120 385
Cara 102 214 233 549

It was the best of times it was the worst of times. It was the age of wisdom, it was the age of foolishness. It was the spring of hope, it was the winter of despair.

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Stage Direct Products ATP Yields
Glycolysis
2 ATP  
2 NADH 3–5 ATP
Pyruvaye oxidation 2 NADH 5 ATP
Citric acid cycle

2 ATP  
6 NADH 15 ATP
2 FADH 3 ATP
30–32 ATP    

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List

List citations

2024

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication
Marco Olguin-Nava, Patrick Bohn, Thomas Hennig, Charlene Börtlein, Anne-Sophie Gribling-Burrer, Nora Schmidt, Neva Caliskan, Lars Dölken, Mathias Munschauer, Redmond P. Smyth
Cold Spring Harbor Laboratory   ·   06 Feb 2024   ·   doi:10.1101/2024.02.05.578560
SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells
Jens Aydin, Alexander Gabel, Sebastian Zielinski, Sabina Ganskih, Nora Schmidt, Christina R Hartigan, Monica Schenone, Steven A Carr, Mathias Munschauer
Nucleic Acids Research   ·   28 Jan 2024   ·   doi:10.1093/nar/gkae038
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
Barbara Trifault, Victoria Mamontova, Giacomo Cossa, Sabina Ganskih, Yuanjie Wei, ..., Peter Gallant, Elmar Wolf, Dorthe H Larsen, Mathias Munschauer, Kaspar Burger
Nucleic Acids Research   ·   15 Jan 2024   ·   doi:10.1093/nar/gkae022

2023

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Nora Schmidt, Sabina Ganskih, Yuanjie Wei, Alexander Gabel, Sebastian Zielinski, ..., Andreas Pichlmair, Steven A. Carr, Petr Chlanda, Florian Erhard, Mathias Munschauer
Cell   ·   01 Oct 2023   ·   doi:10.1016/j.cell.2023.09.002
Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency
David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel
OpenNano   ·   01 Jul 2023   ·   doi:10.1016/j.onano.2023.100161
Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness
Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, Ryan S. Dhindsa, Anne-Sophie Gribling-Burrer, ..., William J. Greenleaf, Anshul Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy
Cold Spring Harbor Laboratory   ·   23 Apr 2023   ·   doi:10.1101/2023.04.23.537997

2022

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, ..., Stuart H. Orkin, Aviv Regev, Timothy L. McCavit, Hitoshi Kanno, Vijay G. Sankaran
Blood   ·   21 Apr 2022   ·   doi:10.1182/blood.2021013753
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, ..., Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai
Nature Communications   ·   23 Feb 2022   ·   doi:10.1038/s41467-022-28508-0

2021

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts
Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, ..., Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann
mBio   ·   29 Jun 2021   ·   doi:10.1128/mbio.02683-20
Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen
Nora Schmidt, Mathias Munschauer
BIOspektrum   ·   01 Jun 2021   ·   doi:10.1007/s12268-021-1587-3

2020

The SARS-CoV-2 RNA–protein interactome in infected human cells
Nora Schmidt, Caleb A. Lareau, Hasmik Keshishian, Sabina Ganskih, Cornelius Schneider, ..., Utz Fischer, Jörg Vogel, Steven A. Carr, Jochen Bodem, Mathias Munschauer
Nature Microbiology   ·   21 Dec 2020   ·   doi:10.1038/s41564-020-00846-z
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer
Minakshi Gandhi, Matthias Groß, Jessica M. Holler, Si’Ana A. Coggins, Nitin Patil, ..., Monica Schenone, Christina R. Hartigan, Heike Allgayer, Baek Kim, Sven Diederichs
Nature Communications   ·   25 Jun 2020   ·   doi:10.1038/s41467-020-17007-9
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation
Anindita Basak, Mathias Munschauer, Caleb A. Lareau, Kara E. Montbleau, Jacob C. Ulirsch, ..., Steven A. Carr, Jane-Jane Chen, Stuart H. Orkin, Eric S. Lander, Vijay G. Sankaran
Nature Genetics   ·   20 Jan 2020   ·   doi:10.1038/s41588-019-0568-7

2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat
Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, ..., Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky, Klaus Rajewsky
Genes & Development   ·   07 Nov 2019   ·   doi:10.1101/gad.330134.119

2018

New insights into the cellular temporal response to proteostatic stress
Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel
eLife   ·   12 Oct 2018   ·   doi:10.7554/eLife.39054
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
Mathias Munschauer, Celina T. Nguyen, Klara Sirokman, Christina R. Hartigan, Larson Hogstrom, ..., Jenny Chen, Monica Schenone, Mitchell Guttman, Steven A. Carr, Eric S. Lander
Nature   ·   27 Aug 2018   ·   doi:10.1038/s41586-018-0453-z
Nuclear lnc RNA stabilization in the host response to bacterial infection
Mathias Munschauer, Jörg Vogel
The EMBO Journal   ·   22 Jun 2018   ·   doi:10.15252/embj.201899875
Quantifying multi-layered expression regulation in response to stress of the endoplasmic reticulum
Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel
Cold Spring Harbor Laboratory   ·   25 Apr 2018   ·   doi:10.1101/308379
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Rajiv K. Khajuria, Mathias Munschauer, Jacob C. Ulirsch, Claudia Fiorini, Leif S. Ludwig, ..., Hanna T. Gazda, Winston Y. Lee, Vikram G. Panse, Steven A. Carr, Vijay G. Sankaran
Cell   ·   01 Mar 2018   ·   doi:10.1016/j.cell.2018.02.036

2017

Developmentally‐faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice
Claudia Fiorini, Nour J. Abdulhay, Sean K. McFarland, Mathias Munschauer, Jacob C. Ulirsch, Roberto Chiarle, Vijay G. Sankaran
American Journal of Hematology   ·   19 Jul 2017   ·   doi:10.1002/ajh.24805

2016

Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Charles P. Fulco, Mathias Munschauer, Rockwell Anyoha, Glen Munson, Sharon R. Grossman, Elizabeth M. Perez, Michael Kane, Brian Cleary, Eric S. Lander, Jesse M. Engreitz
Science   ·   11 Nov 2016   ·   doi:10.1126/science.aag2445

2015

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins
Rebecca Bish, Nerea Cuevas-Polo, Zhe Cheng, Dolores Hambardzumyan, Mathias Munschauer, Markus Landthaler, Christine Vogel
Biomolecules   ·   15 Jul 2015   ·   doi:10.3390/biom5031441
High-Resolution Profiling of Protein-RNA Interactions
Mathias Munschauer
Springer Theses   ·   01 Jan 2015   ·   doi:10.1007/978-3-319-16253-9

2014

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs
Lea H. Gregersen, Markus Schueler, Mathias Munschauer, Guido Mastrobuoni, Wei Chen, Stefan Kempa, Christoph Dieterich, Markus Landthaler
Molecular Cell   ·   01 May 2014   ·   doi:10.1016/j.molcel.2014.03.017
High-resolution profiling of protein occupancy on polyadenylated RNA transcripts
Mathias Munschauer, Markus Schueler, Christoph Dieterich, Markus Landthaler
Methods   ·   01 Feb 2014   ·   doi:10.1016/j.ymeth.2013.09.017
Differential protein occupancy profiling of the mRNA transcriptome
Markus Schueler, Mathias Munschauer, Lea Haarup Gregersen, Ana Finzel, Alexander Loewer, Wei Chen, Markus Landthaler, Christoph Dieterich
Genome Biology   ·   01 Jan 2014   ·   doi:10.1186/gb-2014-15-1-r15

2013

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
Robin Graf, Mathias Munschauer, Guido Mastrobuoni, Florian Mayr, Udo Heinemann, Stefan Kempa, Nikolaus Rajewsky, Markus Landthaler
RNA Biology   ·   01 Jul 2013   ·   doi:10.4161/rna.25194
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti, Francesca Torti, Janna Krueger, ..., Ulrike Ziebold, Markus Landthaler, Christine Kocks, Ferdinand le Noble, Nikolaus Rajewsky
Nature   ·   27 Feb 2013   ·   doi:10.1038/nature11928

2012

FMRP targets distinct mRNA sequence elements to regulate protein expression
Manuel Ascano, Neelanjan Mukherjee, Pradeep Bandaru, Jason B. Miller, Jeffrey D. Nusbaum, ..., Scott Dewell, Markus Hafner, Zev Williams, Uwe Ohler, Thomas Tuschl
Nature   ·   01 Dec 2012   ·   doi:10.1038/nature11737
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
Alexander G. Baltz, Mathias Munschauer, Björn Schwanhäusser, Alexandra Vasile, Yasuhiro Murakawa, ..., Emanuel Wyler, Richard Bonneau, Matthias Selbach, Christoph Dieterich, Markus Landthaler
Molecular Cell   ·   01 Jun 2012   ·   doi:10.1016/j.molcel.2012.05.021

2010

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl
Journal of Visualized Experiments   ·   02 Jul 2010   ·   doi:10.3791/2034
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl
Cell   ·   01 Apr 2010   ·   doi:10.1016/j.cell.2010.03.009

List projects

Cool Dataset
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List team members


List blog posts

2025

Exciting times ahead

We are excited to announce that the Munschauer Lab is moving to the Centre for Integrative Infectious Disease Research (CIID) at Heidelberg University! Our new home at CIID places us at the heart of one of Europe’s leading hubs for biomedical research, where we look forward to expanding our work at the intersection of Molecular Virology, RNA Biology and Sytsems Biology in an inspiring, collaborative environment. We are thrilled about the opportunities ahead and look forward to new scientific partnerships, discoveries, and innovations as we continue to explore the fascinating biology of human pathogenic RNA viruses. Stay tuned for updates as we settle into our new space in Heidelberg!

2024

Our research highlighted in Molecular Cell

Many thanks to Alfredo Castello and co-workers for prominently featuring our lastest work on SND1 and the RNA synthesis mechanism of SARS-CoV-2 in Molecular Cell. Read more

Postdoctoral Fellowship for Lisa Wendt

Congratulations to Lisa Wendt for securing a highly competitive postdoctoral fellowship from the Peter & Traudl Engelhorn Foundation for her work on highly pathogenic RNA viruses in our group. Way to go Lisa!

Award-winning SARS-CoV-2 Research

Nora Schmidt receives the Postdoctoral Award for Virology from the Robert Koch Foundation for her foundational work on SARS-CoV-2 RNA interactions conducted in our lab! Congrats to Nora for this very much deserved recognition. Congrats also to all other lab members who contributed to this important work published in Cell and now prominently recognized by the Foundation. Read more

On the trail of RNA

A big thank you to Helmholtz.de and Kilian Kirchgeßner for a fun interview and a very well crafted profile. If you’re curious about the scientific journey of our PI, you can check it out here -> Read more

SHIFTR - a revolutionary tool for RNA interactomics

We are proud to present SHIFTR, a novel platform for region-specific RNA interactome discovery developed by PhD student Jens Aydin, now published in Nucleic Acid Research. With SHIFTR you can identify proteins directly bound to a specific region within any endogenous or viral RNA. In addition to delivering region-resolution, SHIFTR requires orders of magnitude lower input material compared to the state-of-the-art, thus removing a critical bottleneck. We believe SHIFTR will be a breakthrough technology and look forward to applying it broadly! Read more

Exciting times ahead

Exciting times ahead - the lab is moving to Frankfurt am Main, Germany. We are joining the Institute of Medical Virology at Goethe University Frankfurt. This move has been made possible by generous support from the state of Hesse (LOEWE-Spitzenprofessur) and the Willy Robert Pitzer foundation that will fund our research for the next decade! Read more

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Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Nulla facilisi etiam dignissim diam quis. Id aliquet lectus proin nibh nisl condimentum id venenatis a. Tristique magna sit amet purus gravida quis blandit turpis cursus. Ultrices eros in cursus turpis massa tincidunt dui ut ornare. A cras semper auctor neque vitae tempus quam pellentesque nec. At tellus at urna condimentum mattis pellentesque. Ipsum consequat nisl vel pretium. Ultrices mi tempus imperdiet nulla malesuada pellentesque elit eget gravida. Integer vitae justo eget magna fermentum iaculis eu non diam. Mus mauris vitae ultricies leo integer malesuada nunc vel. Leo integer malesuada nunc vel risus. Ornare arcu odio ut sem nulla pharetra. Purus semper eget duis at tellus at urna condimentum. Enim neque volutpat ac tincidunt vitae semper quis lectus.

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2024

Building Blocks of Understanding: Constructing a Reverse Genetics Platform for studying determinants of SARS-CoV-2 replication
Marco Olguin-Nava, Patrick Bohn, Thomas Hennig, Charlene Börtlein, Anne-Sophie Gribling-Burrer, Nora Schmidt, Neva Caliskan, Lars Dölken, Mathias Munschauer, Redmond P. Smyth
Cold Spring Harbor Laboratory   ·   06 Feb 2024   ·   doi:10.1101/2024.02.05.578560
SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells
Jens Aydin, Alexander Gabel, Sebastian Zielinski, Sabina Ganskih, Nora Schmidt, Christina R Hartigan, Monica Schenone, Steven A Carr, Mathias Munschauer
Nucleic Acids Research   ·   28 Jan 2024   ·   doi:10.1093/nar/gkae038
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts
Barbara Trifault, Victoria Mamontova, Giacomo Cossa, Sabina Ganskih, Yuanjie Wei, ..., Peter Gallant, Elmar Wolf, Dorthe H Larsen, Mathias Munschauer, Kaspar Burger
Nucleic Acids Research   ·   15 Jan 2024   ·   doi:10.1093/nar/gkae022

2023

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Nora Schmidt, Sabina Ganskih, Yuanjie Wei, Alexander Gabel, Sebastian Zielinski, ..., Andreas Pichlmair, Steven A. Carr, Petr Chlanda, Florian Erhard, Mathias Munschauer
Cell   ·   01 Oct 2023   ·   doi:10.1016/j.cell.2023.09.002
Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency
David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel
OpenNano   ·   01 Jul 2023   ·   doi:10.1016/j.onano.2023.100161
Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness
Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, Ryan S. Dhindsa, Anne-Sophie Gribling-Burrer, ..., William J. Greenleaf, Anshul Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy
Cold Spring Harbor Laboratory   ·   23 Apr 2023   ·   doi:10.1101/2023.04.23.537997

2022

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, ..., Stuart H. Orkin, Aviv Regev, Timothy L. McCavit, Hitoshi Kanno, Vijay G. Sankaran
Blood   ·   21 Apr 2022   ·   doi:10.1182/blood.2021013753
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, ..., Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai
Nature Communications   ·   23 Feb 2022   ·   doi:10.1038/s41467-022-28508-0

2021

The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts
Ana Cristina Gonzalez-Perez, Markus Stempel, Emanuel Wyler, Christian Urban, Antonio Piras, ..., Andreas Pichlmair, Lars Dölken, Mathias Munschauer, Florian Erhard, Melanie M. Brinkmann
mBio   ·   29 Jun 2021   ·   doi:10.1128/mbio.02683-20
Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen
Nora Schmidt, Mathias Munschauer
BIOspektrum   ·   01 Jun 2021   ·   doi:10.1007/s12268-021-1587-3

2020

The SARS-CoV-2 RNA–protein interactome in infected human cells
Nora Schmidt, Caleb A. Lareau, Hasmik Keshishian, Sabina Ganskih, Cornelius Schneider, ..., Utz Fischer, Jörg Vogel, Steven A. Carr, Jochen Bodem, Mathias Munschauer
Nature Microbiology   ·   21 Dec 2020   ·   doi:10.1038/s41564-020-00846-z
The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer
Minakshi Gandhi, Matthias Groß, Jessica M. Holler, Si’Ana A. Coggins, Nitin Patil, ..., Monica Schenone, Christina R. Hartigan, Heike Allgayer, Baek Kim, Sven Diederichs
Nature Communications   ·   25 Jun 2020   ·   doi:10.1038/s41467-020-17007-9
Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation
Anindita Basak, Mathias Munschauer, Caleb A. Lareau, Kara E. Montbleau, Jacob C. Ulirsch, ..., Steven A. Carr, Jane-Jane Chen, Stuart H. Orkin, Eric S. Lander, Vijay G. Sankaran
Nature Genetics   ·   20 Jan 2020   ·   doi:10.1038/s41588-019-0568-7

2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat
Verena Labi, Siying Peng, Filippos Klironomos, Mathias Munschauer, Nicolai Kastelic, ..., Stefan Kempa, Leticia Quintanilla-Martinez de Fend, Markus Landthaler, Nikolaus Rajewsky, Klaus Rajewsky
Genes & Development   ·   07 Nov 2019   ·   doi:10.1101/gad.330134.119

2018

New insights into the cellular temporal response to proteostatic stress
Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel
eLife   ·   12 Oct 2018   ·   doi:10.7554/eLife.39054
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
Mathias Munschauer, Celina T. Nguyen, Klara Sirokman, Christina R. Hartigan, Larson Hogstrom, ..., Jenny Chen, Monica Schenone, Mitchell Guttman, Steven A. Carr, Eric S. Lander
Nature   ·   27 Aug 2018   ·   doi:10.1038/s41586-018-0453-z
Nuclear lnc RNA stabilization in the host response to bacterial infection
Mathias Munschauer, Jörg Vogel
The EMBO Journal   ·   22 Jun 2018   ·   doi:10.15252/embj.201899875
Quantifying multi-layered expression regulation in response to stress of the endoplasmic reticulum
Justin Rendleman, Zhe Cheng, Shuvadeep Maity, Nicolai Kastelic, Mathias Munschauer, ..., Markus Landthaler, Lindsay Freeberg, Scott Kuersten, Hyungwon Choi, Christine Vogel
Cold Spring Harbor Laboratory   ·   25 Apr 2018   ·   doi:10.1101/308379
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Rajiv K. Khajuria, Mathias Munschauer, Jacob C. Ulirsch, Claudia Fiorini, Leif S. Ludwig, ..., Hanna T. Gazda, Winston Y. Lee, Vikram G. Panse, Steven A. Carr, Vijay G. Sankaran
Cell   ·   01 Mar 2018   ·   doi:10.1016/j.cell.2018.02.036

2017

Developmentally‐faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice
Claudia Fiorini, Nour J. Abdulhay, Sean K. McFarland, Mathias Munschauer, Jacob C. Ulirsch, Roberto Chiarle, Vijay G. Sankaran
American Journal of Hematology   ·   19 Jul 2017   ·   doi:10.1002/ajh.24805

2016

Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Charles P. Fulco, Mathias Munschauer, Rockwell Anyoha, Glen Munson, Sharon R. Grossman, Elizabeth M. Perez, Michael Kane, Brian Cleary, Eric S. Lander, Jesse M. Engreitz
Science   ·   11 Nov 2016   ·   doi:10.1126/science.aag2445

2015

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins
Rebecca Bish, Nerea Cuevas-Polo, Zhe Cheng, Dolores Hambardzumyan, Mathias Munschauer, Markus Landthaler, Christine Vogel
Biomolecules   ·   15 Jul 2015   ·   doi:10.3390/biom5031441
High-Resolution Profiling of Protein-RNA Interactions
Mathias Munschauer
Springer Theses   ·   01 Jan 2015   ·   doi:10.1007/978-3-319-16253-9

2014

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs
Lea H. Gregersen, Markus Schueler, Mathias Munschauer, Guido Mastrobuoni, Wei Chen, Stefan Kempa, Christoph Dieterich, Markus Landthaler
Molecular Cell   ·   01 May 2014   ·   doi:10.1016/j.molcel.2014.03.017
High-resolution profiling of protein occupancy on polyadenylated RNA transcripts
Mathias Munschauer, Markus Schueler, Christoph Dieterich, Markus Landthaler
Methods   ·   01 Feb 2014   ·   doi:10.1016/j.ymeth.2013.09.017
Differential protein occupancy profiling of the mRNA transcriptome
Markus Schueler, Mathias Munschauer, Lea Haarup Gregersen, Ana Finzel, Alexander Loewer, Wei Chen, Markus Landthaler, Christoph Dieterich
Genome Biology   ·   01 Jan 2014   ·   doi:10.1186/gb-2014-15-1-r15

2013

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation
Robin Graf, Mathias Munschauer, Guido Mastrobuoni, Florian Mayr, Udo Heinemann, Stefan Kempa, Nikolaus Rajewsky, Markus Landthaler
RNA Biology   ·   01 Jul 2013   ·   doi:10.4161/rna.25194
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti, Francesca Torti, Janna Krueger, ..., Ulrike Ziebold, Markus Landthaler, Christine Kocks, Ferdinand le Noble, Nikolaus Rajewsky
Nature   ·   27 Feb 2013   ·   doi:10.1038/nature11928

2012

FMRP targets distinct mRNA sequence elements to regulate protein expression
Manuel Ascano, Neelanjan Mukherjee, Pradeep Bandaru, Jason B. Miller, Jeffrey D. Nusbaum, ..., Scott Dewell, Markus Hafner, Zev Williams, Uwe Ohler, Thomas Tuschl
Nature   ·   01 Dec 2012   ·   doi:10.1038/nature11737
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
Alexander G. Baltz, Mathias Munschauer, Björn Schwanhäusser, Alexandra Vasile, Yasuhiro Murakawa, ..., Emanuel Wyler, Richard Bonneau, Matthias Selbach, Christoph Dieterich, Markus Landthaler
Molecular Cell   ·   01 Jun 2012   ·   doi:10.1016/j.molcel.2012.05.021

2010

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl
Journal of Visualized Experiments   ·   02 Jul 2010   ·   doi:10.3791/2034
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, ..., Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl
Cell   ·   01 Apr 2010   ·   doi:10.1016/j.cell.2010.03.009

Grid of blog posts

2025

Exciting times ahead

We are excited to announce that the Munschauer Lab is moving to the Centre for Integrative Infectious Disease Research (CIID) at Heidelberg University! Our new home at CIID places us at the heart of one of Europe’s leading hubs for biomedical research, where we look forward to expanding our work at the intersection of Molecular Virology, RNA Biology and Sytsems Biology in an inspiring, collaborative environment. We are thrilled about the opportunities ahead and look forward to new scientific partnerships, discoveries, and innovations as we continue to explore the fascinating biology of human pathogenic RNA viruses. Stay tuned for updates as we settle into our new space in Heidelberg!

2024

Our research highlighted in Molecular Cell

Many thanks to Alfredo Castello and co-workers for prominently featuring our lastest work on SND1 and the RNA synthesis mechanism of SARS-CoV-2 in Molecular Cell. Read more

Postdoctoral Fellowship for Lisa Wendt

Congratulations to Lisa Wendt for securing a highly competitive postdoctoral fellowship from the Peter & Traudl Engelhorn Foundation for her work on highly pathogenic RNA viruses in our group. Way to go Lisa!

Award-winning SARS-CoV-2 Research

Nora Schmidt receives the Postdoctoral Award for Virology from the Robert Koch Foundation for her foundational work on SARS-CoV-2 RNA interactions conducted in our lab! Congrats to Nora for this very much deserved recognition. Congrats also to all other lab members who contributed to this important work published in Cell and now prominently recognized by the Foundation. Read more

On the trail of RNA

A big thank you to Helmholtz.de and Kilian Kirchgeßner for a fun interview and a very well crafted profile. If you’re curious about the scientific journey of our PI, you can check it out here -> Read more

SHIFTR - a revolutionary tool for RNA interactomics

We are proud to present SHIFTR, a novel platform for region-specific RNA interactome discovery developed by PhD student Jens Aydin, now published in Nucleic Acid Research. With SHIFTR you can identify proteins directly bound to a specific region within any endogenous or viral RNA. In addition to delivering region-resolution, SHIFTR requires orders of magnitude lower input material compared to the state-of-the-art, thus removing a critical bottleneck. We believe SHIFTR will be a breakthrough technology and look forward to applying it broadly! Read more

Exciting times ahead

Exciting times ahead - the lab is moving to Frankfurt am Main, Germany. We are joining the Institute of Medical Virology at Goethe University Frankfurt. This move has been made possible by generous support from the state of Hesse (LOEWE-Spitzenprofessur) and the Willy Robert Pitzer foundation that will fund our research for the next decade! Read more

Cols

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Code

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